A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
نویسندگان
چکیده
منابع مشابه
A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
متن کاملTitle A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection
Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
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A simulation study was performed to see whether selection affected quantitative trait loci (QTL) mapping. Populations under random selection, under selection among full-sib families, and under selection within a full-sib family were simulated each with heritability of 0.3, 0.5, and 0.7. They were analyzed with the marker spacing of 10 cM and 20 cM. The accuracy for QTL detection decreased for t...
متن کاملA simple linear regression method for quantitative trait loci linkage analysis with censored observations.
Standard quantitative trait loci (QTL) mapping techniques commonly assume that the trait is both fully observed and normally distributed. When considering survival or age-at-onset traits these assumptions are often incorrect. Methods have been developed to map QTL for survival traits; however, they are both computationally intensive and not available in standard genome analysis software package...
متن کاملmapping quantitative trait loci in livestock using simple regression approach
the availability of the saturated dna marker maps in livestock has made it possible to locate quantitative trait loci (qtl) in these domestic animals. the objective of this research was to investigate the principles of applying the simple regression for qtl analysis in paternal half-sib (phs) design commonly used in livestock species. the theoretical aspects of the simple regression approach fo...
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ژورنال
عنوان ژورنال: Behavior Genetics
سال: 2011
ISSN: 0001-8244,1573-3297
DOI: 10.1007/s10519-011-9475-0